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49ers RB Christian McCaffrey ruled out with oblique injury
San Francisco 49ers running back Christian McCaffrey (23) Ken Blaze-USA TODAY Sports

The San Francisco 49ers are having a rough day in more ways than one, and things got worse for them after running back Christian McCaffrey left the game in the fourth quarter.

McCaffrey departed the game with what was determined to be an oblique injury. He briefly returned, but was later seen going to the locker room and was ruled out shortly afterward.

McCaffrey might be the one player the Niners can't afford to lose. He had eight total touchdowns in just five games coming into Sunday’s game and had already added another receiving touchdown on Sunday before his departure. Much of the San Francisco offense runs through him, and they can ill afford to lose him for an extended period of time.

The 49ers also lost another significant piece to injury during Sunday’s game, which turned out to be extremely rough for them on the injury front.

This article first appeared on Larry Brown Sports and was syndicated with permission.

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