Things just keep getting worse for Manchester United after the dropped further down the league table with an embarrassing 3-0 loss to Liverpool at Old Trafford in their last match. Now they have to come back from a two-goal deficit against Olympiakos to advance to the quarterfinals of the Champions League. Midweek Man United were big home Champions League betting favorites at -200 with Olympiakos at +600 and a draw line of +375. [ Check out odds to win the 2014 FIFA World Cup and see where England and Greece are currently ] Olympiakos has already bagged the Greek Super League title and they did so rather easily leading PAOK Thessaloniki FC and Atromitos by 18 points with only one more match remaining. In their 25 league matches they only have two losses and two draws and they have been great on both sides of the pitch. Can Olympiakos win at Old Trafford? Man U has not enjoyed the home field advantage as they usually have on their own pitch and four of their nine losses in EPL play have come there. [ Watch for Champions League odds updates and matchup reports ] Manchester United won the time of possession battle against Olympiakos in the first leg in Greece (60 to 40%), but they only managed seven shots on goal. Robin Van Persie and Wayne Rooney each have 11 goals in EPL play and there is a lot of pressure on this duo to provide some goals against Olympiakos. The Red Devils look out of form as of late mainly in the midfield and if they struggle again in that area of the pitch Olympiakos has a shot. Alejandro Dominguez and Joel Campbell were the players that scored for the Greek side in the first leg and both netted within the first 60 minutes. It will be key that Man U strikes early and if they give up the first goal they may be done. Man U gave up three penalty shots, which led to two goals, in the Liverpool loss and they cannot let that happen in this match. Olympiakos has already wrapped up their domestic league, and did so a while back, so their key players will be well-rested for this big road match. Olympiakos G Roberto Gago is the anchor of the defense and you can be sure that Man U will come out pressing the issue on offense. If they can frustrate the Red Devils like they did in the first leg they will have done their job. The Greek squad will likely pack the defense to protect their two-goal cushion, but the Red Devils have to be wary of the counter attack.