In their last seven games away from Candlestick Park, the San Francisco 49ers are 6-1 SU and ATS. They’ll be tasked with covering a large spread this Sunday when they take on the Jacksonville Jaguars at Wembley Stadium in London, England. The Jaguars are 0-7 SU and 1-6 ATS this season. The 49ers, who are 4-0 SU and ATS over their last four games, are a 16-point favorite on Sunday. Parlaying this obvious wins with some of the other one-sided trends listed below can make for a profitable day of NFL parlay betting (wagering on two or more games together on the same betting ticket). The Miami Dolphins have not fared well on the road against the New England Patriots in recent years, posting a 2-10 SU record in their last 12 trips to Foxboro. New England has been dominant at home in the month of October with a 15-0 SU and 10-4-1 ATS record in its last 15 October home games. The Patriots are 12-1 SU in their last 13 games against division rivals, and are 7-point favorites on Sunday. Going into New Orleans as a 10.5-point underdog, the Buffalo Bills are just 3-9 ATS in their last 12 games as a road underdog. This could spell disaster against the New Orleans Saints, who are 15-3 SU and ATS in their last 18 games as a home favorite. The Saints come out of their bye week at 5-1 SU and 4-2 ATS. [ See the latest NFL odds on this game and every other Week 8 matchup ] Something has to give when the New York Giants visit the Philadelphia Eagles as a 5-point road underdog this Sunday. The Giants are 1-5-1 ATS in their last seven games before heading into a bye, as is the case this week. New York has also had terrible results against Philadelphia in recent years with a 2-9 SU and ATS record against their NFC East rival. But on the other side, Philadelphia is 0-9 SU and ATS in its last nine games at home. Philadelphia’s last home win came in September 2012 against the Giants. Scoring could be at a premium when the Cleveland Browns visit the Kansas City Chiefs on Sunday. The UNDER is 8-1-1 in Kansas City’s last 10 games at home, and in the Chiefs’ last 14 games as a home favorite, the UNDER is 11-2-1. Sunday’s total is currently set at 38.5. Check out NFL computer picks and huge angles in favor of double-digit home underdogs this week at OddsShark.com.