The Pirates go for a sweep of the Diamondbacks Wednesday, the Rangers shoot for a sweep of the Rays and the Giants go for the sweep of the Rockies, while the Reds and Cardinals, Phillies and Mets, and Brewers and Cubs play rubber matches.
Here's a quick look at some of what's happening in baseball over the next couple of days, with some MLB betting odds for contemplation.
Texas (6-2) has taken the first two games of its series with Tampa (3-5) in Arlington by scores of 5-4 and 6-1. For Wednesday's game (2 pm ET) the Rangers with lefty Derek Holland were early -125 favorites over the Rays with lefty Matt Moore.
Defending World Series champion San Francisco has won the first two games of its series at home with Colorado by scores of 4-2 and 9-6. So the Giants have now beaten the Rockies 24 of the last 30 times the teams have met.
For Wednesday's series finale San Fran (5-3) with lefty Barry Zito was an early -135 favorite over the Rocks (5-3) with lefty Jeff Francis.
Philly lost to New York's Matt Harvey Monday night, then bombed Dillon Gee Tuesday night. As for Wednesday's series rubber match (7 pm ET) the Phillies (3-5) with Kyle Kendrick were early -125 chalk over the Mets (5-3) with Jeremy Hefner.
Milwaukee won at Wrigley Field Monday 7-4, then lost Tuesday 6-3. For Wednesday's series finale (8 pm ET) the Brewers (2-6) with newcomer Kyle Lohse hitting the hill were early -115 favorites over the Cubbies (3-5) with newcomer Scott Feldman.
Looking ahead to Thursday the Giants and Cubs begin a four-game weekend series in Chicago; the Yankees finish off a four-game series in Cleveland; the Blue Jays, off to a 2-5 start, finish a three-game series in Detroit; the Orioles and Red Sox complete a three-game set at Fenway; the A's and Angels finish off a three-game series at the Big A; and the White Sox and Nationals play the final match of their three-game series in DC.
Watch for live lines on over unders and runlines as well as live wagering on key matchups.